| Round 1 | BYE | ||||
| Round 2 | THURSDAY 22 FEBRUARY 2018 | LEEDS RHINOS | H | ODSAL STADIUM | 7:30PM |
| Round 3 | FRIDAY 2 MARCH 2018 | ST HELENS | A | BLACKBROOK | 5.15PM |
| Round 4 | BYE | ||||
| Round 5 | THURSDAY 15 MARCH 2018 | CITY OF HULL ACADEMY | H | ODSAL STADIUM | 7:30PM |
| Round 6 | SUNDAY 25 MARCH 2018 | LONDON BRONCOS | A | EALING TRAILFINDERS | 3.00PM |
| Round 7 | THURSDAY 29 MARCH 2018 | WIDNES VIKINGS | A | HALTON STADIUM | 7.00PM |
| Round 8 | THURSDAY 5 APRIL 2018 | CASTLEFORD TIGERS | H | ODSAL STADIUM | 7:30PM |
| Round 9 | THURSDAY 12 APRIL 2018 | ST HELENS | H | DUDLEY HILL | 7.30PM |
| Round 10 | THURSDAY 18 APRIL 2018 | WIGAN WARRIORS | H | ODSAL STADIUM | 7.30PM |
| Round 11 | SATURDAY 28 APRIL 2018 | WARRINGTON WOLVES | H | ODSAL STADIUM | 12:00PM |
| Round 12 | SUNDAY 6 MAY 2018 | LONDON BRONCOS | H | ODSAL STADIUM | 12:30PM |
| Round 13 | BYE | ||||
| Round 14 | FRIDAY 18 MAY 2018 | NEWCASTLE THUNDER | A | KINGSTON PARK | 5:30PM |
| Round 15 | THURSDAY 31 MAY 2018 | WAKEFIELD TRINITY | A | BEAUMONT LEGAL STADIUM | 6:00PM |
| Round 16 | THURSDAY 7 JUNE 2018 | WARRINGTON WOLVES | A | VICTORIA PARK | 7:00PM |
| Round 17 | THURSDAY 14 JUNE 2018 | WIDNES VIKINGS | H | ODSAL STADIUM | 7:30PM |
| Round 18 | THURSDAY 21 JUNE 2018 | CASTLEFORD TIGERS | A | MEND-A-HOSE JUNGLE | 7:00PM |
| Round 19 | THURSDAY 28 JUNE 2018 | HUDDERSFIELD GIANTS | A | LOCKWOOD PARK | 7.00PM |
| Round 20 | FRIDAY 6 JULY 2018 | NEWCASTLE THUNDER | H | ODSAL STADIUM | 5.30PM |
| Round 21 | THURSDAY 12 JULY 2018 | WAKEFIELD TRINITY | H | ODSAL STADIUM | 7:30PM |
| Round 22 | THURSDAY 19 JULY 2018 | LEEDS RHINOS | A | STANNINGLEY ARLFC | 7:00PM |
| Round 3 | FRIDAY 3 AUGUST 2018 | ST HELENS | A | LANGTREE PARK | 7.30PM |
| Round 23 | SATURDAY 11 AUGUST 2018 | WIGAN WARRIORS | A | EDGE HALL ROAD | 2:00PM |
| Round 24 | SUNDAY 19 AUGUST 2018 | HUDDERSFIELD GIANTS | H | ODSAL STADIUM | 12:30PM |
| Round 25 | SATURDAY 8 SEPTEMBER 2018 | CITY OF HULL ACADEMY | A | BISHOP BURTON COLLEGE | 12:00PM |
| FRIENDLY | SATURDAY 15 SEPTEMBER 2018 | CATALANS DRAGONS | H | ODSAL STADIUM | 2PM |